Evidence map›Paper›PMID 40789177›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Inhibition of tenascin C rescues abnormally reduced Na currents in dystrophin-deficient ventricular cardiomyocytes.

Jessica Marksteiner, Jakob Sauer, Martin Hohenegger, Faith-Oluwakemi David, Natalie Schindler, Petra Lujza Szabó, Attila Kiss, Christopher Dostal, Bruno K Podesser, Elena Lilliu and 5 more

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jessica MarksteinerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Jakob SauerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Martin HoheneggerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Faith-Oluwakemi DavidInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0009-0003-1160-4213
Natalie SchindlerInstitute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0009-0009-6111-6617
Petra Lujza SzabóLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0001-5465-8391
Attila KissLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4652-1998
Christopher DostalLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0003-4961-6458
Bruno K PodesserLudwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-4641-7202
Elena LilliuDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Benjamin HacklDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.
Hannes TodtDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-1147-4370
Xaver KoenigDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-2423-4966
Karlheinz HilberDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3033-0874
Klaus SchickerDepartment of Neurophysiology and Neuropharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.ORCID 0000-0002-3068-7830

Funding

Austrian Science Fund (FWF) P35542-BAustrian Science Fund (FWF) P35878-BAustrian Science Fund FWF P 35542Austrian Science Fund FWF P 35878Ludwig Boltzmann Gesellschaft (LBG) CARREM Project Line
6 · The paper itself

Abstract

Cardiac arrhythmias significantly contribute to mortality in Duchenne muscular dystrophy (DMD), a severe muscle disease caused by dystrophin deficiency. Using the

Indexed as

Arrhythmias, CardiacDystrophinMuscular Dystrophy, DuchenneMyocytes, CardiacSodiumTenascinAction PotentialsAnimalsCells, CulturedDisease Models, AnimalHeart VentriclesMaleMiceMice, Inbred C57BLMice, Inbred mdxMice, KnockoutDystrophinNAV1.5 Voltage-Gated Sodium ChannelScn5a protein, mouseSodiumTenascinTnc protein, mousearrhythmiascardiomyopathyDuchenne muscular dystrophyNa currenttenascin C

Identifiers

PMID40789177
PMCPMC7618084

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.