Evidence map›Paper›PMID 40789169›Full record

ReviewJournal of medicinal chemistry2025

Unmasking Conformationally Adaptable Lipids as Drug Receptors.

Steven L Regen

Abstract readReview
In one paragraph

Review in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Steven L RegenDepartment of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015, United States.ORCID 0000-0001-6192-7916

Funding

Nearest-Neighbor Recognition in Lipid BilayersR01GM056149 · NIGMS · LEHIGH UNIVERSITY · PI REGEN, STEVEN L. · 1998 to 2010
$2.6M
NIGMS NIH HHS R01 GM056149
6 · The paper itself

Abstract

This perspective presents evidence that conformationally adaptable lipids that readily conform to the shape of neighboring molecules, can act as receptors for lipophilic drugs. Specifically, Nearest-Neighbor Recognition (NNR) measurements indicate that chloroform, halothane, and isoflurane form 1:1 complexes with 1,2-dipalmitoyl-

Indexed as

1,2-DipalmitoylphosphatidylcholineLipidsCholesterolErythrocytesHumansModels, MolecularMolecular ConformationPharmaceutical PreparationsSpectrum Analysis, Raman1,2-DipalmitoylphosphatidylcholineCholesterolLipidsPharmaceutical Preparations

Identifiers

PMID40789169
PMCPMC12406197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.