ArticleACS infectious diseases2025
Collaborative Synthesis for Neglected Diseases through the Open Synthesis Network: Structure-Activity Relationships of Arylaminopyrazoles as Chagas Disease Treatments.
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Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1citing papers in PubMed
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1 citing paper in PubMed.
- Fluorophenylalanine-Containing Dipeptides with Antibiofilm Activity AgainstMolecules (Basel, Switzerland) · 2026Article
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Authors and funding
79 authors.
Zigli AbdulaiDepartment of Chemistry, University of Ghana, P.O. Box LG56, Legon, Accra LG56, Ghana.
Natasha AgboDepartment of Chemistry, University of Ghana, P.O. Box LG56, Legon, Accra LG56, Ghana.
Jonathan I AndersonSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Faye AstleySchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Brian ChanDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Owen Atkinson-EvansSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
João L AvelarLaboratório de Avaliação e Síntese de Substâncias Bioativas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Rio de Janeiro 20000-000, Brazil.
Cristiane Aparecida-SilvaLaboratório de Avaliação e Síntese de Substâncias Bioativas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Rio de Janeiro 20000-000, Brazil.
K D BhardwajSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
William J BowleySchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Nicholas BreitkreuzSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Rosie CanbySchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Emerald CartwrightSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Charles CliffordSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Shannon A CordellSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
William J DonkerSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Joseph DriscollSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Matthew GradySchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Lauren HigginbothamSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Devon HsuDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Jamie HutchinsonSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Lukas ImbergInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany.
Harry F JacksonSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Finan JohnsSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Emma JonesSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Dmitrii V KalininInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany.
Ceren KardeşlerSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Aaron KealSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Libby KeelSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Sumin KimDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Phoebe KnightSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Justus F KödelOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, Bayreuth 95440, Germany.
Luke KumetaSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Hyejin LeeDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Sam Le RoySchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Rachelle MaccaroneDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Maria MahmudSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Matthew MartinSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Ignatius NguyenDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Conor J NolanSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Lucy NoyesSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Angela N W NtuwaSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Wiktoria ObarskaSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Owen OldhamSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Edna OnyiukeDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Jess OtterSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Hugh PageSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Dhruvi PatelDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Kayla ReidDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Krishna SamaddarSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Sheryar M ShabbirSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Peter ShevlinDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Callum Sinclair-WrightSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Amanda SmithiesSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Amelia S ThomsonSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Jack TinkerSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.ORCID 0009-0000-8543-1982
Alexander UnerSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Natascha Van PeltOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, Bayreuth 95440, Germany.
Ewan WaddellSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Hamis WagwaDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Claire WalthorneSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Sophie WarnerSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Tobias WingeInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany.
Ngai Sum WongSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Leon Jan WysockiSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Callum A YongSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.
Zaria ZaheenDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
An MatheeussenLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B-2610, Belgium.ORCID 0000-0002-7507-1634
Guy CaljonLaboratory of Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Universiteitsplein 1, Wilrijk B-2610, Belgium.ORCID 0000-0002-4870-3202
Richard AmewuDepartment of Chemistry, University of Ghana, P.O. Box LG56, Legon, Accra LG56, Ghana.ORCID 0000-0002-4676-436X
Anna BertramSchool of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, U.K.ORCID 0000-0002-4468-1923
Bernhard BiersackOrganic Chemistry Laboratory, University of Bayreuth, Universitätsstrasse 30, Bayreuth 95440, Germany.ORCID 0000-0001-7305-346X
Carolyn FrielDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Lídia Moreira LimaLaboratório de Avaliação e Síntese de Substâncias Bioativas, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, Rio de Janeiro 20000-000, Brazil.ORCID 0000-0002-8625-6351
Chase SmithDepartment of Pharmaceutical Sciences, School of Pharmacy-Worcester/Manchester, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, Massachusetts 01608, United States of America.
Bernhard WünschInstitut für Pharmazeutische und Medizinische Chemie der Westfälischen Wilhelms-Universität Münster, Corrensstraße 48, Münster D-48149, Germany.ORCID 0000-0002-9030-8417
Benjamin PerryDrugs for Neglected Diseases Initiative, 15 Chemin Camille Vidart, Geneva 1202, Switzerland.ORCID 0000-0001-6715-4213
Luiza R CruzDrugs for Neglected Diseases Initiative, Rio de Janeiro 20010020, Brazil.ORCID 0000-0001-6103-9345
Andrew NortcliffeGlaxoSmithKline Carbon Neutral Laboratories for Sustainable Chemistry, School of Chemistry, University of Nottingham, Triumph Road, Nottingham NG7 2TU, U.K.ORCID 0000-0002-3371-390X
Funding
Regional Medical Libraries for the Network of the National Library of Medicine: Region 7 & NPHCOUG4LM012347 · NLM · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Mary Elizabeth Piorun · 2016 to 2026
$22.3MNLM NIH HHS UG4 LM012347
Abstract
Neglected tropical diseases (NTDs) make up a diverse group of debilitating illnesses disproportionately affecting impoverished communities in tropical and subtropical regions. Despite their significant global health burden, they are often overshadowed by more prominent diseases, resulting in a critical lack of investment in the research and development of new treatments. A renewed focus on NTDs is, therefore, urgently needed, particularly in terms of novel therapeutic strategies. The Open Synthesis Network, launched by DNDi and partner institutions in 2016, is an innovation powerhouse that taps into the potential of students to help drive the discovery of new drugs for patients living with NTDs. We present the results of student-led work into the development of a series of aminopyrazoles for Chagas disease, a multisystemic disease caused by the
Indexed as
Chagas DiseaseNeglected DiseasesPyrazolesTrypanocidal AgentsTrypanosoma cruziAnimalsDrug DiscoveryHumansStructure-Activity RelationshipPyrazolesTrypanocidal Agentsdrug discoveryeducationinfectious diseasesNTDsopen innovationparasitesstructure−activity relationshipsTrypanosoma cruzi
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