Evidence map›Paper›PMID 40788612›Full record

ArticlePain and therapy2025

Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China: A Retrospective, Database, Multicenter Study (ReTARdant) Protocol.

Qi Pan, Xiaoyu Zhai, Haining Wang, Jianling Du, Yanxia Shi, Xuefeng Yu, Sunjie Yan, Xiaohong Wu, Hui-Hui Li, Tao Sun and 3 more

Registry-linked trialAbstract read
In one paragraph

Article in Pain and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06546202 (Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06546202 completednot on this map

Real-World Pharmacological Treatment Pattern of Neuropathic Pain in China: A Retrospective, Database, Multi-center Study (ReTARdant)

TypeobservationalSponsorDaiichi SankyoRan2024 to 2025Enrolled1,271ConditionsDiabetic Peripheral Neuropathic Pain, Chemotherapy-induced Peripheral Neuropathy, Neuropathic PainArmsNo Drug
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qi Pan *Department of Endocrinology, Beijing Hospital, Beijing, China.
Xiaoyu Zhai *Department of Thoracic Medical Oncology, Peking University Cancer Hospital and Institute, Beijing, China.
Haining Wang *Department of Pain Medicine, China-Japan Friendship Hospital, Beijing, China.
Jianling DuDepartment of Endocrinology, The First Affiliated Hospital of Dalian Medical University, Dalian, China.
Yanxia ShiDepartment of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, China.
Xuefeng YuDepartment of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sunjie YanDepartment of Endocrinology, The First Affiliated Hospital Fujian Medical University, Fuzhou, China.
Xiaohong WuDepartment of Endocrinology, Zhejiang Provincial People's Hospital, Hangzhou, China.
Hui-Hui LiDepartment of Breast Medical Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China.
Tao SunDepartment of Medical Oncology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital, Shenyang, China.
Lixin GuoDepartment of Endocrinology, Beijing Hospital, Beijing, China. glx1218@163.com.
Jun ZhaoDepartment of Thoracic Medical Oncology, Peking University Cancer Hospital and Institute, Beijing, China. ohjerry@163.com.
Bifa FanDepartment of Pain Medicine, China-Japan Friendship Hospital, Beijing, China. bf1616@yeah.net.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeuropathic pain (NP), including diabetic peripheral neuropathic pain (DPNP) and chemotherapy-induced peripheral neuropathy (CIPN) as common subtypes, imposes a significant clinical burden on patients, severely affecting their quality of life. The real-world evidence on demographic characteristics, treatment patterns, and adherence data of DPNP and CIPN is still limited.

methodsA multicenter, retrospective, observational study using electronic medical record (EMR) systems involving approximately 600 patients with DPNP and 400 with CIPN from nine hospitals was planned. The study period extended from January 1, 2017 to December 31, 2022, which includes the enrollment period, pre-enrollment period, and observation period. Included patients will be adult (aged ≥ 18 years) diagnosed with DPNP or CIPN and receiving at least one index regimen, with index date defined as the initiation date of index regimen. At least one medical record within 12 months after index date will also be required for inclusion. The observation period is defined as the period from the index date to the end of the study data collection for at least 12 months. PLANNED OUTCOMES: The primary objective is to describe the demographics, clinical characteristics, and treatment patterns, including types and proportion of treatment regimens, treatment discontinuation/switching/add-on, restarting after discontinuation, duration of index regimen, and time to treatment add-on. The secondary and exploratory measures include the dosing pattern and real-world adherence of regimens.

trial registrationNCT06546202 (ClinicalTrials.gov).

Indexed as

Chemotherapy-induced peripheral neuropathyDiabetic peripheral neuropathic painDosing patternReal-world adherenceTreatment pattern

Identifiers

PMID40788612
PMCPMC12484476

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.