ArticleMikrochimica acta2025
A portable electrochemical sensor for simultaneous voltammetric determination of multiple neurotransmitters using magnetic composite nanozyme.
Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A portable electrochemical sensor for simultaneous voltammetric determination of acetylcholine (Ach), serotonin (5-HT) and dopamine (DA) using magnetic multi-walled carbon nanotubes-decorated ferroferric oxide-Pt@Au nanoparticles (FM-Pt@AuNPs) composite nanozyme was developed. The application of the nanozyme perfectly solved the problem of the weak electroactivity of Ach and the overlapping electrochemical signal of 5-HT and DA. Benefiting from superior horseradish peroxidase (HRP)-like activity and huge specific surface area of the FM-Pt@AuNPs, the proposed sensor enabled to quantify ACh, 5-HT, and DA at the potential of + 0.9, + 0.35, and + 0.14 V, with detection limits of 2 nM, 15 nM, and 10 nM, respectively. The assay provides good analytical performances and clinical practicability in human serums samples. This is the first detection of Ach, 5-HT, and DA using voltammetry, and it is also a new attempt of nanozyme in the field of portable electrochemical sensors. The strategy could be used for detecting other small biomolecules, and provide a simple and potential way for early-stage diagnosis and management of neurological diseases.
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