Evidence map›Paper›PMID 40788577›Full record

ArticleAbdominal radiology (New York)2026

Dual-energy CT to evaluate the infiltration status of tumor-associated macrophage (TAM) in gastric cancer: a preliminary study.

Hua Shi, Wan Yang, Xiangmei Qiao, Lin Li, Song Liu

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Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Hua Shi *Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321, Zhongshan Road, Nanjing, Jiangsu Province, 210008, China.
Wan Yang *Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321, Zhongshan Road, Nanjing, Jiangsu Province, 210008, China.
Xiangmei QiaoDepartment of Ultrasound, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321, Zhongshan Road, Nanjing, Jiangsu Province, 210008, China.
Lin LiDepartment of Pathology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321, Zhongshan Road, Nanjing, Jiangsu Province, 210008, China. lilinpathology@163.com.
Song LiuDepartment of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, No. 321, Zhongshan Road, Nanjing, Jiangsu Province, 210008, China. liusongnj@126.com.

Funding

Medical Science and Technology Development Foundation, Nanjing Commission of Health YKK22079the National Natural Science Foundation of China 82001885
6 · The paper itself

Abstract

purposeTo explore the relationship between tumor-associated macrophages (TAMs) in gastric cancer and dual-energy computed tomography (DECT) parameters.

methodsThis retrospective study was conducted with patients who underwent both DECT examination and gastric cancer resection. 89 patients (mean age ± standard deviations, 64.36 ± 9.37) were finally enrolled and analyzed. DECT parameters included iodine concentration (IC), normalized IC (NIC), effective atomic number (Z

resultsCD206+ TAM infiltration density demonstrated statistically significant weak correlations with several DECT parameters in LAP (r = 0.236-0.258, all P < 0.05) rather than in VP in all 89 patients. In 48 tubular adenocarcinoma (TAC) patients, correlations in LAP were weak-to-moderate and involved more parameters (r = 0.287-0.358, all P < 0.05), while no significant correlations existed in poorly cohesive carcinoma (PCC). Z

conclusionDECT parameters in LAP showed weak to moderate correlations with TAM infiltration density in gastric adenocarcinoma. These correlations were statistically significant in TAC but absent in PCC. DECT has the potential to assess TAM infiltration density in an exploratory and adjuvant manner, though its assessment efficacy is affected by different WHO subtypes and heterogeneity of gastric cancer.

Indexed as

Radiography, Dual-Energy Scanned ProjectionStomach NeoplasmsTomography, X-Ray ComputedTumor-Associated MacrophagesAgedContrast MediaFemaleHumansMaleMiddle AgedRetrospective StudiesStomachContrast MediaDual-energy CTStomach neoplasmTubular adenocarcinomaTumor-associated macrophage

Identifiers

PMID40788577

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.