ArticleDiscover oncology2025
Knowledge mapping of ferroptosis in sarcoma: a bibliometric and bioinformatics analysis (2012-2023).
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- A scientometric and comparative study of rhabdomyosarcoma research by pediatricians and stomatologists.Journal of dental sciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSarcoma is a rare and heterogeneous group of malignant tumors originating from mesenchymal tissues, which presents significant challenges for diagnosis and treatment. Ferroptosis, a newly recognized form of iron-dependent cell death, is distinct from other cell death mechanisms such as apoptosis and autophagy. Recent studies have shown that the induction of ferroptosis is an effective way to kill sarcoma cells and reduce their resistance to chemotherapeutic drugs, highlighting the importance of understanding how ferroptosis may influence the biology and treatment of sarcomas.
methodsIn this study, we employed three main methods, namely CiteSpace, VOSviewer, and the R package "bibliometrix", to analyze relevant literature. Publications related to ferroptosis and sarcoma in the Science Citation Index Expanded of the Web of Science Core Collection (WoSCC) database (2012-2023) were included, and bioinformatics analyses were performed using R Studio and public databases.
resultsThe analysis revealed that research on sarcomas and ferroptosis has experienced a steady increase over the years, with a diverse range of research topics and collaborations established among researchers worldwide. The key findings include the identification of influential authors and institutions, prominent research clusters, and emerging research trends. The bioinformatics analysis results confirmed the significance of ferroptosis-related gene ACSF2 in different sarcomas. Notably, the scarcity of studies focusing on the relationship between sarcoma and ferroptosis has been observed, highlighting the potential for further exploration in this area.
conclusionThe integration of bibliometrics and bioinformatics provides valuable insights into the research landscape of sarcoma and ferroptosis. Future research on ferroptosis will continue to focus on its mechanisms in sarcomas including immune microenvironment, while also further exploring its potential clinical applications. We have identified a potential ferroptosis-related gene, ACSF2, which shows associations with survival in sarcoma datasets. Further testing is needed to validate its potential as a prognostic biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.