SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025
Neutrophil cell surface receptor dynamics following trauma: a systematic review.
Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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Who cites it
4 citing papers in PubMed.
- International comparison of neutrophil surface markers after severe trauma is feasible using point of care flowcytometry - results from a pilot study.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Structural diversity of lipid A modulates neutrophil proteome and secretome responses.Journal of proteomics · 2026Article
- The Mediating Effect of Inflammatory Biomarkers in the Associations Between Sarcoidosis and Incident Ischemic Stroke: A Prospective Cohort Study.Brain and behavior · 2026Article
- Defining the early systemic neutrophil signature after severe trauma: decreased CD10/CD16 levels on admission precedes metabolic dysregulation.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNeutrophils are essential effector cells in the immune response to traumatic injury. Although changes in receptor expression over time have been described in the literature, effective monitoring strategies are still lacking. This systematic review aims to identify reported neutrophil cell surface receptor dynamics after trauma and to determine the post-traumatic neutrophil signature over time, forming the basis for future immunomonitoring.
methodsWe conducted a systematic review to identify clinical studies describing neutrophil cell surface expression levels of relevant markers in the field of trauma. Reported post-traumatic alterations were gathered and pooled.
resultsA total of 1,266 publications were identified that used neutrophil phenotype in a clinical setting, of whom 34 were utilized for data extraction. The most frequently analyzed receptors were Mac-1/CD11b (n = 25), L-selectin/CD62L (n = 9). Fifteen studies investigated the Fcγ-receptor family. CD11b increases after moderate to severe trauma, peaking at 24 h, then decreases over 6 months. L-selectin shows early fluctuations, whereas CD16 decreases homogeneously after trauma. CD64, as well as other less well-described markers (CD13, CD46, CD55, CD59) show homogenous alterations following injury.
conclusionsThis study is the first comprehensive review on post-traumatic neutrophil receptor dynamics. By pooling available data from literature, a unique multi-parameter post-traumatic neutrophil signature, with both traditional neutrophil markers (CD11b, CD11a, CD62L, CD16, CD64) and novel markers has been identified. Future combining of these markers and subset analysis may form the basis for post-traumatic immunomonitoring.
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