ArticleJournal of neural transmission (Vienna, Austria : 1996)2026
White matter alterations in tremor-dominant and postural instability and gait disturbance subtypes of Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Relationship between excessive daytime sleepiness and motor subtype transition in untreated prodromal Parkinson's disease: a cohort study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Lithium as a disease-modifying therapy for Parkinson's disease: mechanisms, preclinical evidence, and clinical prospects.Clinical parkinsonism & related disorders · 2026Review
- Differential brain iron deposition in Parkinson's disease subtypes: a comparative quantitative susceptibility mapping study of tremor-dominant versus postural instability/gait difficulty phenotypes.Frontiers in neurologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
backgroundTremor dominant Parkinson's disease (TDPD) and postural instability and gait disturbance (PIGD) are clinically defined motor subtypes of PD with significant differences in clinical phenotype, prevalence of non-motor symptoms (NMS), rate of progression and underlying pathophysiology.
objectiveTo evaluate white matter microstructural integrity in TDPD and PIGD motor subtypes of PD to ascertain subtype specific patterns of involvement.
methodsData was analysed for 162 subjects - TDPD (n = 74), PIGD (n = 54) and HC (n = 34) who were prospectively recruited. All subjects underwent detailed clinical assessment including the MDS-UPDRS, MDS-NMS, and motor subtyping was based on the ratio of mean TD/PIGD score (≥ 1.15:TD, ≤ 0.90: PIGD) from the MDS-UPDRS. 3T multi-shell diffusion weighted imaging data was acquired and processed. Diffusion metrics of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) were considered for tract based spatial statistics and evaluation of whole tract measures.
resultsThe PIGD group exhibited widespread reductions in FA and increases in MD, RD, and AD in motor, associative, and limbic tracts, consistent across voxel-wise and tract-level analyses. TDPD showed limited alterations. White matter changes in PIGD correlated with higher motor and non-motor symptom severity, particularly involving corticospinal, fronto-occipital, and cingulum tracts.
conclusionsThe PIGD variant of PD has significantly widespread alterations involving diffusion metrics of numerous dopaminergic and non-dopaminergic tracts involved in distinct motor and non-motor symptoms. These may be the basis for the phenotypic variations and differences in severity observed between these motor subtypes.
Indexed as
Identifiers
40788494What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.