ArticleProbiotics and antimicrobial proteins2026
Probiotic Lactobacillus Strains Mitigate Chlorpyrifos-Induced Lung and Heart Toxicity in Rats via Anti-inflammatory and Antioxidant Mechanisms.
Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Comparative Interaction of Pesticides with Microplastics and Soil Organic Matter: A Molecular Simulation Study.Toxics · 2026Article
- Bacillus velezensis alleviates PMAnimal microbiome · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chlorpyrifos (CPF), a widely used organophosphorus pesticide, induces adverse effects such as organ toxicity, endocrine disruption, oxidative stress, and histopathological damage in non-target organisms. Emerging evidence suggests that lactic acid bacteria (LABs) can alleviate CPF-induced tissue damage. This study investigated the protective effects of probiotic lactobacilli against subacute CPF toxicity in the heart and lungs of rats. Eight groups of male Sprague‒Dawley rats were exposed to CPF and probiotics for 6 weeks. CPF toxicity triggered lipid peroxidation, evidenced by a 40% and 60% rise in malondialdehyde (MDA) levels in heart and lung tissues, respectively. Additionally, CPF significantly elevated superoxide dismutase (SOD) and IL-1β, indicating oxidative and pro-inflammatory responses. Probiotic treatment effectively suppressed CPF-induced increases in MDA, SOD, and IL-1β. Histopathological analysis demonstrated that Lactobacillus acidophilus (heart) and Lactobacillus casei (lungs), particularly the probiotic bacterial mixture in each respective tissue, attenuated CPF-induced tissue damage. In conclusion, probiotic supplementation mitigates CPF-mediated cardiotoxicity and pulmonary toxicity by modulating antioxidant and inflammatory pathways.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.