ArticleDiscover oncology2025
Gut microbiota and breast cancer risk: a Mendelian randomization study stratified by ER status.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Obesity-related Metabolic Dysfunction and Triple-negative Breast Cancer: Epidemiologic Signals, Mechanistic Pathways, and Opportunities for Prevention.Current obesity reports · 2026Review
- Obovatol induces apoptosis in breast cancer by downregulating the PI3K/Akt pathway.Translational cancer research · 2026Article
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5 authors.
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Abstract
backgroundThe potential causal relationship between gut microbiota (GM) and breast cancer (BC), particularly its estrogen receptor (ER)-positive (ER+) and ER-negative (ER-) subtypes, remains insufficiently characterized.
methodWe conducted a two-sample Mendelian randomization (MR) analysis to examine genetically predicted causal associations between 473 GM features (abundance in stool) and BC, including overall BC (Ncase = 24,270, Ncontrol = 222,078), ER+ BC (Ncase = 14,540, Ncontrol = 221,705) and ER- BC (Ncase = 9,724, Ncontrol = 221,705).
resultThe MR results demonstrated differential causal associations between GM and BC subtypes: For overall BC risk, lower Barnesiella abundance (OR = 0.93; 95%CI 0.88-0.98; P = 0.006) was protective, whereas higher Providencia abundance (OR = 1.30; 95%CI 1.11-1.51; P = 0.0008) increased risk. Among ER+ BC cases, five GM showed significant associations: Dokdonella (OR = 1.38; 95%CI 1.12-1.70; P = 0.0024), Flavonifractor sp900199495 (OR = 0.81; 95%CI 0.69-0.94; P = 0.0054), Rhodanobacter (OR = 1.45; 95%CI 1.10-1.92; P = 0.0087), Ruminococcus (OR = 0.73; 95%CI 0.58-0.92; P = 0.0080), and UBA7177 sp002491225 (OR = 1.33; 95%CI 1.08-1.63; P = 0.0067). In ER- BC, seven GM factors exhibited causal relationships: Bacteroides A plebeius (OR = 0.90; 95%CI 0.84-0.97; P = 0.0077), CAG-273 sp003507395 (OR = 0.89; 95%CI 0.82-0.95; P = 0.0009), CAG-390 sp003523225 (OR = 0.82; 95%CI 0.71-0.95; P = 0.0064), CAG-433 (OR = 0.86; 95%CI 0.78-0.95; P = 0.0030), Chromobacteriaceae (OR = 0.57; 95%CI 0.39-0.83; P = 0.0034), Providencia (OR = 1.48; 95%CI 1.18-1.86; P = 0.0007), and Syntrophorhabdaceae (OR = 1.52; 95%CI 1.14-2.04; P = 0.0050).
conclusionsOur genetically informed MR analysis provides suggestive evidence for the differential causal roles of specific GM in overall, ER + and ER- BC pathogenesis, offering potential biomarkers for therapeutic intervention strategies.
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