ArticleJournal of materials science. Materials in medicine2025
Poloxamer-based hydrogel with EGCG and rhEGF for diabetic foot ulcer treatment.
Article in Journal of materials science. Materials in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Poloxamer/HPMC/Carbopol-Based Thermosensitive Hydrogel Loaded with Ibuprofen for Potential Vaginal Drug Release.Gels (Basel, Switzerland) · 2026Article
- Enhanced oral delivery and bioactivity of EGCG via DNA nanocarriers.Scientific reports · 2026Article
- Comprehensive Review of Hydrogel-Mediated Strategies for Diabetic Wound Healing.International journal of molecular sciences · 2026Review
- Hydrogel-Delivered Recombinant Fibronectin DK1 Promotes Diabetic Wound Healing by Boosting Cellular Responses.Biomolecules · 2026Article
- Efficacy and Safety Analysis of Concentrated Growth Factor Combined with Photorejuvenation for Sensitive Skin Patients: A Retrospective Cohort Study.Clinical, cosmetic and investigational dermatology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A thermosensitive hydrogel dressing was developed for the healing of diabetic foot ulcers (DFUs) using Epigallocatechin gallate (EGCG) and recombinant human epidermal growth factor (rhEGF). Hyaluronic acid (HA), poloxamer 407 (P407), and pectin (PE) were used to form the sol-gel transition matrix, which exhibited a sol-to-gel transition around 30 °C. The hydrogel was physiologically stable. Structural and morphological characterization using Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron microscopy (SEM), and transmission electron microscopy (TEM) confirmed the efficient incorporation of EGCG and rhEGF in a porous nanoarchitecture. Rheological analysis showed the storage modulus is quite constant over the frequency range (0.01-10 Hz), and compression analysis showed a compressive strength of 40.85 kPa, ensuring mechanical appropriateness for various wound conditions. This hydrogel had a water content of 76.64% and a water vapor transmission rate of 6011.44 g/m
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Registered trials
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