Evidence map›Paper›PMID 40788415›Full record

SynthesisEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2025

Crystalloid vs colloid fluid resuscitation in polytrauma patients: a systematic review.

Julia Dormann, Karolina Dahms, Eva Steinfeld, Kelly Ansems, Heidrun Janka, Maria-Inti Metzendorf, Thomas Breuer, Klemens Horst, Frank Hildebrand, Gernot Marx and 1 more

Abstract readSystematic ReviewComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Independence of the mortality of severely injured patients from types of transport and hospital level in a well-developed trauma network.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julia DormannDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Karolina DahmsDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Eva SteinfeldDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Kelly AnsemsDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Heidrun JankaInstitute of General Practice, Medical Faculty of the Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
Maria-Inti MetzendorfInstitute of General Practice, Medical Faculty of the Heinrich-Heine-University Dusseldorf, Dusseldorf, Germany.
Thomas BreuerDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Klemens HorstDepartment of Orthopaedics, Trauma and Reconstructive Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Frank HildebrandDepartment of Orthopaedics, Trauma and Reconstructive Surgery, Medical Faculty, RWTH Aachen University, Aachen, Germany.
Gernot MarxDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany.
Carina BenstoemDepartment of Intensive Care Medicine and Intermediate Care, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 52074, Aachen, Germany. cbenstoem@ukaachen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe question of whether crystalloid or colloid fluid yields better outcomes in the treatment of polytrauma patients has recently garnered significant interest. This systematic review aims to comprehensively compare the effects of crystalloid versus colloid fluid resuscitation on treatment outcomes in polytrauma patients.

methodsWe searched PubMed, Cochrane Central Register of Controlled Trials and Web of Science to identify completed and ongoing studies from inception of each database to August 9, 2022. We included systematic reviews and randomized controlled trials (RCTs) comparing crystalloid versus colloid fluid resuscitation on treatment outcomes in polytrauma patients admitted to the intensive care unit (ICU).

resultsWe included one RCT with a total of 2,857 adult participants (mean age 63 years in the colloids and crystalloids group, 62.2% male in the colloids group and 62.5% male in the crystalloids group). Our findings indicate that the administration of crystalloids does not significantly differ from colloids in terms of 28-day mortality among polytrauma patients. (HR 1.19; 95% CI 0.54 to 2.62; RD 23 more per 1000, 95% CI 58 fewer to 174 more, 1 study, 177 participants, very low quality of evidence).

conclusionCrystalloid volume therapy has no significant difference on adult polytrauma patients compared to colloid volume therapy regarding mortality.

Indexed as

Crystalloid SolutionsFluid TherapyMultiple TraumaResuscitationColloidsHumansRandomized Controlled Trials as TopicColloidsCrystalloid SolutionsColloidCrystalloidIntensive care medicinePolytrauma

Identifiers

PMID40788415
PMCPMC12339606

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.