Evidence map›Paper›PMID 40788375›Full record

ArticleDigestive diseases and sciences2026

The Relationship Between Esophageal Motility Disorders and Varicella Zoster Virus: A Study Using Salivary DNA.

Satsuki Takahashi, Tomoaki Matsumura, Michiko Sonoda, Tatsuya Kaneko, Ryosuke Horio, Chihiro Goto, Akane Kurosugi, Tsubasa Ishikawa, Yuki Ohta, Takashi Taida and 3 more

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Article in Digestive diseases and sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Satsuki TakahashiDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Tomoaki MatsumuraDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan. matsumura@chiba-u.jp.ORCID http://orcid.org/0000-0001-5314-9325
Michiko SonodaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Tatsuya KanekoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Ryosuke HorioDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Chihiro GotoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Akane KurosugiDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Tsubasa IshikawaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Yuki OhtaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Takashi TaidaDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Masato NakamuraDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Kenichiro OkimotoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.
Jun KatoDepartment of Gastroenterology, Graduate School of Medicine, Chiba University, Inohana 1-8-1, Chiba City, 260-8670, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe causes of most esophageal motility disorders (EMDs) remain unknown. Recent reports have suggested a potential association between the EMD achalasia and varicella zoster virus (VZV) reactivation. This study aimed to investigate the relationship between various EMDs and VZV infection.

methodsThis was cross-sectional study. The participants in this study underwent high-resolution manometry (HRM) at Chiba University Hospital between 2022 and 2024. Saliva and blood samples were collected from all patients. The presence of VZV DNA in the saliva was determined using nested polymerase chain reaction (PCR) and electrophoresis. VZV-immunoglobulin M and immunoglobulin G antibody titers were measured in the blood samples. Based on the HRM results, the patients were divided into an EMD group and a normal group. The results were compared between these groups.

resultsA total of 72 patients were included. Of these, 32 (44.4%) were in the normal group and 40 (55.6%) were in the EMD group, including 22 with esophagogastric junction (EGJ) outflow disorders (achalasia and EGJ outflow obstruction) and 18 with peristalsis disorders (absent contractility, distal esophageal spasm, hypercontractile esophagus, and ineffective esophageal motility). One patient with absent contractility had a concurrent herpes zoster infection, and VZV DNA was detected in this patient's saliva. However, all other patients tested negative for VZV DNA. No significant difference in VZV antibody titers was observed between the two groups.

conclusionsVZV DNA in the saliva and VZV antibody titers do not appear to be associated with EMDs.

Indexed as

DNA, ViralEsophageal Motility DisordersHerpesvirus 3, HumanSalivaVaricella Zoster Virus InfectionAdultAgedCross-Sectional StudiesFemaleHumansMaleManometryMiddle AgedDNA, ViralEsophageal motility disordersNested PCRSalivary DNAVaricella zoster virus

Identifiers

PMID40788375
PMCPMC12909326

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.