Observational studyInfection2025
Blood transcriptomic for the diagnosis of nosocomial infections in critically ill patients: an observational proof-of-concept study.
Observational study in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The Tip of the Iceberg: Pathway Biology Must Anchor the Next Generation of Critical Care Trials.Critical care explorations · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe assessment of genetic activation has shown good diagnostic capacity in identifying sepsis in patients at the emergency department or upon admission to the intensive care unit. This study evaluates a gene expression diagnostic test for identifying nosocomial infections in critically ill patients and compares it with well-established tests used in routine clinical practice.
methodsThis was a prospective, observational, non-interventional study conducted in a single intensive care unit of a tertiary university hospital. Adult critically ill patients were enrolled if their attending physician suspected a nosocomial ICU-acquired infection, and a comprehensive microbiological study was performed. The genetic host response was assessed using the SeptiCyte RAPID assay at study inclusion, alongside microbiological, analytical, and radiological evaluations.
resultsSixty-nine patients were enrolled, of whom 78.3% (n 54) received empirical antimicrobial treatment. ICU-acquired infection was confirmed in 35 patients (50.7%). A bacterial etiology was established in 32 cases (91.4%), and viral reactivation was diagnosed in 2 cases (5.7%). Diagnostic capacity was measured as follows: procalcitonin AUC 0.600 (95% CI 0.454-0.745), C-reactive protein AUC 0.703 (95% CI 0.564-0.839) and Septi-Cyte RAPID AUC 0.995 (95% CI 0.930-1.003). The optimal cut-off point for Septi-cyte score was 6.35, yielding a sensitivity of 91.4%, specificity of 73.5%, and positive and negative predictive values of 78% and 89.3%, respectively.
conclusionsGenetic activation analysis in patients with suspected ICU-acquired nosocomial sepsis demonstrated good diagnostic capability, even surpassing traditional inflammatory biomarkers.
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Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.