Primary tenosynovial giant cell tumor arising in the nasal cavity with molecular confirmation: the first reported case.

Wenyi Jing, Lalai Ainiwaer, Xin He

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 authors.

Wenyi Jing *Department of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, 610041, Chengdu, Sichuan, China.

Lalai Ainiwaer *West China School of Medicine, Sichuan University, Chengdu, China.

Xin HeDepartment of Pathology, West China Hospital, Sichuan University, Guoxuexiang 37, 610041, Chengdu, Sichuan, China. 498818978@qq.com.ORCID http://orcid.org/0000-0002-3941-1494

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tenosynovial giant cell tumors (TGCT) arising in the head and neck region are rare, and to date, no primary TGCT originating in the nasal cavity has been reported. Here, we report an extremely rare primary TGCT in the nasal cavity in a 28-year-old female. Computed tomography scan revealed a soft tissue density nodule measuring 1.6 × 1.4 cm in the left nasal cavity. Histologically, the tumor is mainly composed of mononuclear cells with round to oval nuclei, mild to moderate atypia. Scattered multinucleated giant cells and nests of foamy histiocytes were also identified. FISH analysis detected CSF1 gene rearrangement. Next-generation sequencing identified a CBL gene missense mutation (c. 1250C > G/ p.P417R). To the best of our knowledge, this is the first example of genetically confirmed TGCT in the nasal cavity. Our study broadens the anatomical spectrum of TGCT and highlights the inclusion of TGCT in the differential diagnosis of nasal cavity lesions.

Indexed as

Giant Cell Tumor of Tendon SheathNasal CavityNose NeoplasmsAdultBiomarkers, TumorFemaleHigh-Throughput Nucleotide SequencingHumansIn Situ Hybridization, FluorescenceMutation, MissenseBiomarkers, TumorCSF1 gene rearrangementHead and neck regionNasal cavityNoseTenosynovial giant cell tumors

Identifiers

PMID40788343

DOI10.1007/s00428-025-04221-3

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