ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2025
M2c Macrophages Mediate YAP1 to Promote Vascularized Bone Regeneration in Distraction Osteogenesis.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Mechanical‑immune feedback regulation in distraction osteogenesis: From mechanotransduction to immune microenvironment remodeling (Review).Molecular medicine reports · 2026Review
- Sequential polarization of macrophages: an immunomodulatory strategy for novel bone repair materials.Regenerative biomaterials · 2026Review
- Neuro-immune-vascular-stem cell crosstalk in bone/cartilage regeneration: mechanisms, technological advances, and clinical perspectives.Frontiers in bioengineering and biotechnology · 2026Review
- M2c Macrophages Mediate YAP1 to Promote Vascularized Bone Regeneration in Distraction Osteogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Distraction osteogenesis (DO) is an efficient approach to addressing craniofacial deformities and bone defects. M2c macrophages play a crucial role in the formation of bone tissue; however, the underlying mechanism during the immunoregulation related to angiogenic osteogenesis remains unclear. In this study, we first isolate the cell culture medium from M2c macrophages to induce HUVECs and confirm the angiogenic ability. Then RNA-sequencing data identified key genes in M2c macrophages, verified by PCR and immunofluorescence (IF). Furthermore, siRNA inhibited YAP1 in HUVECs, after which the angiogenic activity of these cells and their effect on the vascular osteogenesis of BMSCs were evaluated through proliferation, migration, tube formation, and osteo-differentiation assays. In vivo, the rat mandibular DO model was established, YAP1 inhibitors were injected, and osteogenesis was investigated using micro-CT, H&E, Masson, and IHC staining. The M2c polarization in HUVECs enhanced their proliferation, migration, and tube formation abilities, which were reduced by the downregulated expression levels of YAP1. PCR and WB analyses revealed that inhibiting YAP1 expression in M2c could disrupt the expression levels of VEGF, FGF, and ANG1 in HUVECs, consequently diminishing their angiogenic capabilities. Moreover, HUVEC
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.