Evidence map›Paper›PMID 40788148›Full record

ArticleVeterinary medicine and science2025

Comparative Clinico-Haematological Alterations of Lumpy Skin Disease Affected Cattle at Different Ages and Periods of Disease in Bangladesh.

Md Saiful Islam Siddiqui, Md Ashiqur Rahman, Saiful Islam, Papri Rani Dey, Md Khademul Islam, Sultana Begum, Md Masudur Rahman

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Article in Veterinary medicine and science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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5 · Who and what money

Authors and funding

7 authors.

Md Saiful Islam SiddiquiDepartment of Anatomy & Histology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.ORCID 0000-0003-4995-1782
Md Ashiqur RahmanIntern veterinarian, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.ORCID 0009-0004-6834-9206
Saiful IslamDepartment of Anatomy & Histology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.
Papri Rani DeyIntern veterinarian, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.
Md Khademul IslamMS Fellow, Department of Epidemiology & Public Health, Sylhet Agricultural University, Sylhet, Bangladesh.
Sultana BegumDepartment of Physiology and Pharmacology, Jhenaidah Govt. Veterinary College, Jhenaidah, Bangladesh.ORCID 0009-0007-8548-0267
Md Masudur RahmanDepartment of Pathology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet, Bangladesh.ORCID 0000-0001-7095-9303

Funding

Government of the Peoples Republic of Bangladesh 2023-26Sylhet Agricultural University Research SystemUniversity Grants Commission
6 · The paper itself

Abstract

objectivesLumpy skin disease (LSD) is a transboundary viral pox disease that causes huge economic losses. The disease is in an epidemic situation, and the affected cattle show massive lesions and complexity, which is tough to treat; thus, a study was conducted to investigate the clinico-haematological alterations of LSD-affected cattle for adopting better pharmacotherapeutic management. MATERIAL AND

methodsA total of 36 LSD affected, and 8 healthy/control cattle were examined and used for blood profiling. The control and affected cattle were categorized into four age groups consisting of nine cattle (Group A = under 1 year; Group B = 1 to 2 years; Group C = 2 to 3 years; and Group D = from 4 years up to 10 years) in each group and three disease periods of post infection (prodromal period, period of illness and period of decline) consist of each of 12 LSD affected cattle.

resultsClinical examination of affected cattle showed 100% cattle (skin nodule of various sizes), 55.55% (lymph node enlargement), 75% (high fever), 13.88% (brisket oedema), 19.44% (limb oedema), 8.33% (ventral abdomen oedema), 5.55% (facial oedema), 19.44% (lameness), 22.22% (respiratory distress), 2.77% (corneal opacity) and 27.78% (salivation and nasal discharge) as clinical signs. Almost all affected cattle showed multiple lesion at the same time, particularly in the last two disease periods. Comparatively, the nodular lesion is much more higher in the limb (33.1%), followed by the head and neck region (23.24%), and then other parts of the body. Haematological analysis reveals a significant decrease in red blood cell (RBC), haemoglobin (Hb), packed cell volume (PCV), mean corpuscular Hb concentration (MCHC), TLC and thrombocytes. During the illness and decline periods, mean corpuscular volume (MCV) increased, which is an indication of macrocytic hypochromic anaemia, lymphocytopenia and thrombocytopenia, and indicative of fluid therapy such as blood transfusion. The age group under 1 year is more vulnerable to LSD fatality, as lower levels of TLC, lymphocyte, and monocyte were found, indicating severe immunosuppression.

conclusionIt is concluded that disease stage-wise and age-wise clinico-haematological studies have provided baseline data of LSD pathogenesis, which is essential to formulate an effective pharmacotherapeutic strategy.

Indexed as

Lumpy Skin DiseaseLumpy skin disease virusAge FactorsAnimalsBangladeshCattleFemaleMaleage categorydisease stagehaematologyinvestigationlumpy skin disease (LSD)

Identifiers

PMID40788148
PMCPMC12337385

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