ReviewInfection and immunity2025
Consequences of host-microbiome interactions in preterm infants.
Review in Infection and immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Hospitalisations for respiratory tract infections in preterm and term born children aged 1-5 years before, during and after COVID-19 control measures: an interrupted time-series analysis.BMJ paediatrics open · 2026Article
- Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment.Journal of translational medicine · 2026Review
- Unveiling the viral dimension: The paediatric gut virome as a key modulator of gastrointestinal metabolic, and neurodevelopmental health.World journal of virology · 2026Review
- The Link Between Preterm Birth and Long-Term Renal Consequences: Current Knowledge and Emerging Therapeutic Targets.Biomedicines · 2026Review
- Probiotic-conditioned microbiota from preterm infants modulate immune response to pathogen challenge in a microbiota-humanized mouse model.Frontiers in immunology · 2026Article
- Early supplementation with live combinedFrontiers in cellular and infection microbiology · 2026Observational
- Longitudinal Fecal Short-Chain Fatty Acid Trajectories in Preterm Infants with Early-Onset Neonatal Sepsis: A Pilot Study.Life (Basel, Switzerland) · 2025Article
- The role of gut microbiota in the onset and development of sepsis and its therapeutic potential: mechanisms and research progress.Frontiers in microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Preterm infants are highly susceptible to bacterial infections and inflammatory diseases. These vulnerabilities arise from disruptions in gut microbiome structure and function, immune system immaturity, and underdeveloped organ systems. In this review, we explore the role of the gut microbiome in neonatal health. With a specific focus on preterm infants, we outline how microbiome disruption contributes to negative clinical outcomes. First, we provide an overview of infant gut microbiome development, highlighting key factors that influence its trajectory. Next, we examine the interplay between the infant gut microbiome and the development of systemic and intestinal immune systems, with emphasis on how microbiome perturbations related to preterm birth alter host-microbiome interactions and the overall immune landscape. We then discuss the role of altered gut composition in disease states common to preterm infants, such as sepsis, bacterial infections, and necrotizing enterocolitis. Finally, we discuss current and future diagnostics and treatments and offer our perspective on future research to untangle the host-microbiome interface in early life.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.