ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Article
- p300: expanding beyond acetylation to mastermind lactylation-dependent tumorigenesis.Frontiers in cell and developmental biology · 2026Review
- H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A-Driven EP300 Expression.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
Abstract
Human pluripotent stem cells (hPSCs) can transition between primed and naive states, each defined by unique epigenetic features crucial for early human development. However, the precise regulatory mechanisms of these transitions, particularly involving the roles of H3K27ac and m6A modifications, remain unclear. Here, it is revealed that H3K27ac is essential for establishment of human naive pluripotency. This elevation is critical for maintaining the naive state, as inhibiting H3K27ac disrupts naive pluripotency, while enhancing it promotes the naive state. Furthermore, it is discovered that m6A, via the enzyme METTL3, indirectly controls H3K27ac by regulating EP300 expression, an enzyme involved in H3K27ac deposition. METTL3 overexpression suppresses EP300 protein, thereby reducing H3K27ac modification and impeding naive pluripotency. These findings uncover a novel interplay between H3K27ac and m6A, advancing the understanding of stem cell regulation. This work provides new insights into the epigenetic control of hPSCs, with potential implications for developmental biology and regenerative medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.