Evidence map›Paper›PMID 40788087›Full record

ArticleBiomacromolecules2025

Fluorinated Redox-Responsive Cross-Linked Poly(amidoamine) G2 as Smart Theranostic Dendrimers.

Carola Romani, Maria Cristina Bellucci, Maria Enrica Di Pietro, Paola Gagni, Mattia Sponchioni, Alessandro Volonterio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomacromolecules, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carola RomaniDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, Milano 20131, Italy.ORCID 0009-0006-5041-6743
Maria Cristina BellucciDepartment of Food, Environmental, and Nutritional Sciences, Università degli Studi di Milano, via Celoria 2, Milano 20131, Italy.
Maria Enrica Di PietroDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, Milano 20131, Italy.ORCID 0000-0002-2370-1948
Paola GagniConsiglio Nazionale delle Ricerche, Istituto di Scienze e Tecnologie Chimiche "Giulio Natta" (SCITEC), Via Mario Bianco 9, Milan 20131, Italy.ORCID 0000-0002-3652-6173
Mattia SponchioniDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, Milano 20131, Italy.ORCID 0000-0002-8130-6495
Alessandro VolonterioDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, via Mancinelli 7, Milano 20131, Italy.ORCID 0000-0002-0125-0744

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This work presents a novel strategy for enhancing the gene delivery capabilities of low-generation poly(amidoamine) (PAMAM) dendrimers by employing a fluorinated, redox-responsive cross-linker. The synthesized cross-linker, featuring both disulfide bonds and trifluoromethyl groups, facilitates efficient "click" Michael addition with PAMAM G2, producing cross-linked polymers with strong

Indexed as

DendrimersPolyaminesTheranostic NanomedicineCross-Linking ReagentsDNAGene Transfer TechniquesHalogenationHeLa CellsHumansOxidation-ReductionTransfectionCross-Linking ReagentsDendrimersDNAPAMAM StarburstPoly(amidoamine)Polyamines

Identifiers

PMID40788087
PMCPMC12421505

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.