Evidence map›Paper›PMID 40788055›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Hepatic ENTPD5 Is Critical for Maintaining Metabolic Homeostasis and Promoting Brown Adipose Tissue Thermogenesis.

Rufeng Ma, Song Hou, Rui Xiang, Wenjun Liu, Xin Li, Yujing Chi, Ming Xu, Haochen Yao, Jing Li, Jichun Yang

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rufeng MaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.
Song HouDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.
Rui XiangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.
Wenjun LiuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.
Xin LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.
Yujing ChiDepartment of Central Laboratory and Institute of Clinical Molecular Biology, Department of Gastroenterology, Peking University People's Hospital, Beijing, 100044, China.
Ming XuDepartment of Cardiology, Peking University Third Hospital, Beijing, 100191, China.
Haochen YaoHepatobiliary and Pancreatic Surgery Department, General Surgery Center, First Hospital of Jilin University, No.1 Xinmin Street, Changchun, Jilin, 130021, China.
Jing LiDepartment of Endocrinology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, China.ORCID https://orcid.org/0000-0002-1352-2196
Jichun YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Center for Non-coding RNA Medicine, Peking University Health Science Center, Beijing, 100191, China.ORCID https://orcid.org/0000-0001-8150-2923

Funding

Beijing Natural Science Foundation 7212123National Key Research and Development Program of China 2020YFA0803800National Key Research and Development Program of China 2020YFA0803803National Natural Science Foundation of China 82300957/82370824/82230024/82025008/82470858/U20A20345Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0523100
6 · The paper itself

Abstract

Although hepatocyte-released adenosine triphosphate (ATP) plays important roles in maintaining metabolic homeostasis, how its hydrolyzation outside hepatocytes impacts on glucolipid metabolism remains unclear. The authors aim to identify the enzyme(s) that hydrolyzes hepatocyte-secreted ATP to regulate metabolic homeostasis. All known ATP-hydrolyzing enzymes are expressed with the highest expression of ectonucleoside triphosphate diphosphohydrolase 5 (ENTPD5) in hepatocytes. ENTPD5 expression is reduced in steatotic mouse and human livers. Hepatic ENTPD5 overexpression ameliorates the deregulated glucolipid metabolism and obesity with increased brown adipose tissue (BAT) thermogenesis, while hepatic ENTPD5 silencing exerted the opposite effects in obese mice. Mechanistically, ENTPD5 hydrolyzes extracellular ATP to ADP, which activates purinergic receptor, P2Y

Indexed as

Adipose Tissue, BrownHomeostasisLiverPyrophosphatasesThermogenesisAnimalsHepatocytesHumansMaleMiceMice, Inbred C57BLNon-alcoholic Fatty Liver DiseaseObesityPyrophosphatasesadenosine triphosphate metabolismadrenomedullinbrown adipose tissue thermogenesisectonucleoside triphosphate diphosphohydrolase 5

Identifiers

PMID40788055
PMCPMC12561356

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.