Evidence map›Paper›PMID 40788053›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Precision-Arranged DNA Origami Plasmonic Nanoantennas for Multidimensional Smart-Warning of Weightlessness Induced Bone Loss.

Yufan Ling, Xuan Qin, Weijia Sun, Fan Yue, Yiwei Wang, Di Fan, Haoyuan Xu, Ruao Xie, Jiawei Zhang, Jianwei Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yufan LingState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, 215123, P. R. China.
Xuan QinSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Weijia SunNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, 100094, P. R. China.
Fan YueSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Yiwei WangState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, 215123, P. R. China.
Di FanSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Haoyuan XuSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Ruao XieSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Jiawei ZhangSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.
Jianwei LiNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, 100094, P. R. China.
Bingyan LiDepartment of Nutrition and Food Hygiene, School of Public Health, Soochow University, Suzhou, 215123, P. R. China.
Yang YangDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, 200433, P. R. China.
Yingxian LiNational Key Laboratory of Space Medicine, China Astronaut Research and Training Center, Beijing, 100094, P. R. China.
Houyu WangSuzhou Key Laboratory of Nanotechnology and Biomedicine, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou, Suzhou, 215123, P. R. China.ORCID https://orcid.org/0000-0002-5134-9881
Guangming ZhouState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, 215123, P. R. China.

Funding

Collaborative Innovation Center of Suzhou Nano Science and TechnologyNational Key Research and Development Program of China 2022YFA1104300National Key Research and Development Program of China 2023YFB3208200National Natural Science Foundation of China 22074101National Natural Science Foundation of China 52325106National Natural Science Foundation of China 82192883Priority Academic Program Development of Jiangsu Higher Education InstitutionsShenzhen Science and Technology Innovation Program SYW2024068
6 · The paper itself

Abstract

Surface-Enhanced Raman Scattering (SERS) shows promise for monitoring health during space missions, particularly in assessing the effects of microgravity and radiation. However, traditional SERS sensors struggle with precise interfacial engineering, leading to a relatively poor assembly efficiency, and are unable to meet the practical needs of extreme spaceflight environments. To address this, it is designed and fabricated precision-arranged DNA origami plasmonic nanoantennas. By leveraging DNA origami's addressability, it is built a 3 × 4 antenna array with a controlled spacing of 21.76 nm, enhancing assembly efficiency fourfold compared to disordered systems. The ordered system enabled accurate detection of calcium ions, interleukin-6, and microRNA-214 in serum from mice exposed to microgravity and radiation, with intraclass correlation coefficients > 0.75, comparable to ELISA and qPCR. More importantly, integrating the system with a convolutional neural network enabled precise bone health prediction. This platform provides a promising tool for astronaut health monitoring.

Indexed as

Bone ResorptionDNAWeightlessnessAnimalsMiceMicroRNAsSpace FlightSpectrum Analysis, RamanDNAMicroRNAsbone Lossdeep learningDNA origamisensorspaceflight

Identifiers

PMID40788053
PMCPMC12561424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.