Epidemiology, clinical characteristics, and outcome of enterococcal bloodstream infections in critically ill patients in China: a single-center retrospective 10-year analysis.

Enterococcal bloodstream infections (BSIs) in critically ill patients are linked to multidrug resistance (MDR), high morbidity, and increased mortality. We conducted a retrospective cohort study over a decade at a 3,500-bed teaching hospital, including intensive care unit patients diagnosed with enterococcal BSIs. Data on demographics, comorbidities, severity scores, treatments, and microbiological profiles were analyzed. Risk factors for infection and mortality were assessed using multivariate logistic regression. Among 101 patients, IMPORTANCE: Enterococcal bloodstream infections are a serious concern in critically ill patients, often associated with multidrug resistance (MDR) and high mortality rates. This study highlights the importance of early intervention, including source control and timely antimicrobial therapy, in improving patient outcomes. By identifying key risk factors for mortality, such as comorbidities, male sex, and delayed treatment, this research provides valuable insights for clinicians in managing these infections. Notably, the study emphasizes the crucial role of early removal of central venous catheters and targeted therapy in reducing mortality risk. These findings underscore the need for effective infection prevention strategies and timely clinical decisions in critically ill patients. This work lays the foundation for future research aimed at optimizing treatment approaches and combating the growing challenge of MDR