ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2025
Area Deprivation and Pediatric Cancer Mortality: An Analysis of 2000 to 2020 State Cancer Registry Data.
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Area-Based Marginalization and Incidence of Childhood Cancer.JAMA network open · 2026Article
- Health Insurance as a Mediator of Neighborhood Deprivation and Pediatric Cancer Survival: An Analysis of State Cancer Registry Data.Cancer medicine · 2026Article
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8 authors.
Funding
Abstract
backgroundCompared with adult cancers, less research has been conducted on health disparities in pediatric cancer outcomes. The effect of neighborhood deprivation, as measured by the Area Deprivation Index (ADI), on pediatric cancer survival is not well understood, especially among diverse populations.
methodsWe conducted a population-based longitudinal study using data from the Iowa Cancer Registry and Louisiana Tumor Registry. The study included children ages 0 to 19 years diagnosed with cancer in Iowa and Louisiana from 2000 to 2020. The primary exposure was ADI, and the primary outcome was cancer-specific mortality. Cox regression models with shared frailty to account for the geographic clustering of individuals were used to compute the association between ADI and mortality.
resultsA total of 6,982 children were included between the two states: 2,939 in Iowa and 4,043 in Louisiana. In the adjusted analysis, higher deprivation was positively associated with poorer pediatric cancer survival. Compared with children in the least deprived neighborhoods, those in the most deprived neighborhoods had a 50% higher risk of cancer death [95% confidence interval (CI), 1.18-1.89] and a 3.15 times greater risk of early cancer death (95% CI, 1.39-7.16). Among children with extracranial solid tumors, those in the most deprived neighborhoods had a 54% higher risk of cancer death (95% CI, 1.04-2.27) compared with those in the least deprived neighborhoods.
conclusionsHigher ADI is associated with higher pediatric cancer mortality, highlighting the importance of social drivers of health on pediatric cancer outcomes. IMPACT: Neighborhood-level interventions will likely be needed to improve pediatric cancer outcomes.
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