ArticlemBio2025
The growth benefits and toxicity of quinone biosynthesis are balanced by a dual regulatory mechanism and substrate limitations.
Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Menaquinone biosynthesis inEngineering microbiology · 2026Review
- Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments.Nature biotechnology · 2026Article
- Metabolic Engineering Strategy forFoods (Basel, Switzerland) · 2025Review
- Synthetic microbial co-cultures for modular bioelectronic sensing in diverse environments.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Quinones play a central role in maintaining redox balance and conserving energy but can trigger oxidative stress at high levels. However, the mechanisms by which microbes regulate quinone levels remain poorly understood, hindering effective metabolic engineering to modulate microbes for quinone production. Here, we show that the biosynthesis of the menaquinone precursor 1,4-dihydroxy-2-naphthoic acid (DHNA) in the lactic acid bacterium IMPORTANCE: Quinones are crucial molecules in cellular respiration, helping cells produce energy and maintain balance in their redox state. However, excessive quinone levels can be toxic, making it vital for microbes to tightly regulate their production. Our study uncovers how
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