Evidence map›Paper›PMID 40787975›Full record

ArticleeLife2025

Hexokinase regulates Mondo-mediated longevity via the PPP and organellar dynamics.

Raymond Laboy, Marjana Ndoci, Shamsh Tabrez Syed, Maximilian Vonolfen, Eugen Ballhysa, Tim Droth, Klara Schilling, Anna Loehrke, Ilian Atanassov, Adam Antebi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Raymond LaboyDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.ORCID https://orcid.org/0000-0002-0375-1550
Marjana NdociDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Shamsh Tabrez SyedDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Maximilian VonolfenDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Eugen BallhysaDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Tim DrothDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Klara SchillingDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Anna LoehrkeDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.
Ilian AtanassovDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.ORCID https://orcid.org/0000-0001-8259-2545
Adam AntebiDepartment of Molecular Genetics of Ageing, Max Planck Institute for Biology of Ageing, Cologne, Germany.ORCID https://orcid.org/0000-0002-7241-3029

Funding

EU Erasmus Fellowship
6 · The paper itself

Abstract

The transcriptional complex Mondo/Max-like, MML-1/MXL-2, acts as a convergent transcriptional regulatory output of multiple longevity pathways in

Indexed as

Basic Helix-Loop-Helix Leucine Zipper Transcription FactorsCaenorhabditis elegansCaenorhabditis elegans ProteinsHexokinaseLongevityPentose Phosphate PathwayTranscription FactorsAnimalsBasic Helix-Loop-Helix ProteinsCell NucleusGene Expression RegulationGene Knockdown TechniquesMitochondriaBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHexokinaseHLH-30 protein, C elegansTranscription FactorsC. eleganscell biologyhexokinasehumanlongevitymetabolismMML-1MondoA

Identifiers

PMID40787975
PMCPMC12339002

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.