Observational studyPaediatric anaesthesia2025
A Single-Center Descriptive Analysis of Interventions for Hypotension in Children: A Retrospective Cohort Study.
Observational study in Paediatric anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Management of arterial hypotension in critically Ill children: a narrative review and practical approach.Frontiers in pediatrics · 2026Review
- Preoperative Clear Fluid Fasting Duration and Arterial Hypotension During Anesthesia Induction: A Narrative Review.Journal of clinical medicine · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIntraoperative hemodynamic management goals in pediatric patients vary significantly with age. Physiologic variability and the absence of a widely accepted definition of intraoperative hypotension contribute to inconsistent treatment thresholds and practice variation.
aimsThe primary aim was to observe which blood pressure thresholds in various age groups led to clinical intervention in noncardiac surgery. The secondary aim was to determine the most commonly employed treatment interventions.
methodsA single-center, retrospective, observational cohort study analyzed anesthesia records for 37 958 pediatric patients aged < 18 years of age who underwent noncardiac surgery and general anesthesia at our institution from January 1, 2015, through December 31, 2023. Age groups included: infants (0-12 months), preschool (1-6 years), children (7-12 years), and teenagers (13-17 years). The primary outcome was the adjusted rate of intervention, defined as any bolus of ephedrine, phenylephrine, epinephrine, norepinephrine, vasopressin, or 5% albumin. An algorithmic approach was used to examine the time epoch both before (6 min) and after (3 min) any study-defined interventions to identify the lowest mean arterial pressure that was associated with an intervention.
resultsFollowing exclusions, 37 958 anesthetic records were analyzed in this cohort. The median arterial pressure value and interquartile range associated with an intervention were: 36 mmHg [29, 43] in infants, 44 mmHg [38.5, 52] in preschool, 51 mmHg [44, 58] in children, and 57 mmHg [51, 63] in teenagers. The most common intervention was 5% albumin, followed by phenylephrine.
conclusionIntervention rates in pediatric patients were lower than those reported in adults, with intervention thresholds decreasing with younger age. Use of intravascular volume expansion appears to be more commonly used to treat hypotension in infants compared to older children. These findings highlight the need for multicenter studies to establish standardized intervention thresholds and assess their impact on clinical outcomes.
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