ArticleACS applied bio materials2025
Transforming Human Amniotic Membrane into Nanoparticles: An Approach for Cardiac Delivery Systems.
Article in ACS applied bio materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Cardiovascular disease remains the leading cause of death worldwide, with heart failure due to irreversible damage to heart muscle cells posing a major therapeutic challenge. Although current surgical and pharmacological interventions offer some benefits, there is an urgent need for innovative strategies to promote cardiac repair and regeneration. Recent efforts have focused on developing cost-effective, minimally invasive therapies that use controlled delivery systems to precisely target therapeutic agents, such as drugs, genes, or cells, while enhancing efficacy and minimizing side effects. Nanoparticles (NPs) have emerged as a promising solution, offering targeted delivery with reduced toxicity. In this study, we developed amniotic membrane-derived NPs (AMPs) from decellularized human amniotic membrane (DAM). The resulting AMPs exhibited nanoscale size, mild positive surface charge, and a sustained drug-release profile, making them well-suited for cardiac applications. Encapsulation of a fluorescent dye demonstrated their efficient drug-loading capacity and potential for noninvasive imaging.
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