Evidence map›Paper›PMID 40787879›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Fabrication of Site-Specific 3D Structures via Macroscopic Supramolecular Assembly for Spatially Controlled Alignment of Multiple Cells.

Yuchen Liu, Rui Ming, Qian Zhang, Yuguang Wang, Yijing Liu, Yuriy G Galyametdinov, Andrey Knyazev, Feng Shi, Fang Liu, Mengjiao Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuchen LiuState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID https://orcid.org/0000-0002-5206-7608
Rui MingState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Qian ZhangState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID https://orcid.org/0000-0002-7225-7791
Yuguang WangDepartment of General Dentistry II, National Center for Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Peking University School and Hospital of Stomatology, No.22, Zhongguancun South Avenue, Haidian, Beijing, 100081, China.
Yijing LiuState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.
Yuriy G GalyametdinovDepartment of Physical and Colloid Chemistry, Kazan National Research Technological University, 68 Karl Marx street, Kazan, 420015, Russia.
Andrey KnyazevDepartment of Physical and Colloid Chemistry, Kazan National Research Technological University, 68 Karl Marx street, Kazan, 420015, Russia.
Feng ShiState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID https://orcid.org/0000-0001-5897-5116
Fang LiuChina-Japan Friendship Hospital, East Yinghuayuan Street 2, Chaoyang District, Beijing, 100029, China.
Mengjiao ChengState Key Laboratory of Chemical Resource Engineering, Beijing Laboratory of Biomedical Materials, Beijing Advanced Innovation Centre for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.ORCID https://orcid.org/0000-0002-1137-3545

Funding

Beijing Nova Program 20230484440Beijing Nova Program 20240484541Fundamental Research Funds for the Central Universities QNTD20National Key Research and Development Program of China 2021YFC2103900National Natural Science Foundation of China 52122315National Natural Science Foundation of China 52303292National Science Fund for Distinguished Young Scholars 51925301Open Project of State Key Laboratory sklssm202511Wanren Plan wrjh201903
6 · The paper itself

Abstract

The self-assembly of micrometer-to-millimeter components, referred to as "macroscopic supramolecular assembly (MSA)," offers an efficient approach for constructing cell-scale 3D bioactive structures with flexible modular designs. Compared with available 3D bio-printing or conventional modular assembly of cell-material units, MSA is advantageous in decoupling material preparation and cell loading processes by directing cell adhesion after the preparation of 3D structures, which minimizes the trade-off between cell viability and material selection. But the challenge lies in efficient self-sorting of different cells and spatially controlled cell distribution. Hence, MSA is combined with the surface chemistry of orthogonally specific peptides to different cells and magnetic manipulation, and fabricated 3D bioactive structures that direct cell sorting. Microscale polydimethylsiloxane (PDMS) components are modified with 1) Arg-Glu-Asp-Val and Val-Ala-Pro-Gly peptides affinitive to endothelial cells (ECs) and smooth muscle cells (SMCs), respectively, and 2) host/guest molecules as "supramolecular glues" for precise structuring and interfacial bonding. Self-sorting and spatially controlled adhesion of ECs and SMCs is achieved to mimic layered vascular structures. This "Lego-like" strategy is free of compromising cell viability with structure design, thus contributing to spatially intricate and bioactive 3D architectures, and promoting the development of MSA from fundamental advances to applications.

Indexed as

OligopeptidesPrinting, Three-DimensionalCell AdhesionCell SurvivalDimethylpolysiloxanesEndothelial CellsHumansMyocytes, Smooth MusclePeptidesSurface Propertiesarginyl-glutamyl-aspartyl-valinebaysilonDimethylpolysiloxanesOligopeptidesPeptidesvalyl-alanyl-prolyl-glycine3D ordered structurehost/guest interactionmacroscopic supramolecular assemblymodular assemblyselective cell adhesion

Identifiers

PMID40787879
PMCPMC12412592

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.