ArticleAngewandte Chemie (International ed. in English)2025
Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC-MS.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Local Chemical Gradients in a Mammalian Cortex Measured In Vivo With a Silicon Nanodialysis Mass Spectrometry Platform.Angewandte Chemie (International ed. in English) · 2026Article
- Large-scale electrophysiology at single-spike resolution.Nature reviews. Neuroscience · 2026Review
- Neuropeptides in the Extracellular Space of the Mouse Cortex Measured In Vivo by Nanodialysis Probe Coupled with LC-MS.Angewandte Chemie (International ed. in English) · 2025Article
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Authors and funding
7 authors.
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Abstract
Neuropeptides are key neuromodulators in the central nervous system that shape sensory processing, yet their extracellular dynamics in the somatosensory cortex (S1) remain poorly understood. This study applies an innovative membrane-free silicon nanodialysis (ND) probe coupled with liquid chromatography-mass spectrometry (LC-MS) to analyze the extracellular neuropeptidome in the mouse S1 with spatial resolution down to 100 µm. Localized in vivo sampling identified extracellular peptides from secretogranin-1, ProSAAS, pro-opiomelanocortin (POMC), and others. Minimal tissue damage, enabled by probe dimensions of 75 × 15 µm
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Registered trials
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