ArticleInternational journal of women's health2025
Pregnancy Outcomes Following Assisted Reproductive Technology in Advanced Maternal Age Primiparous Women: A Retrospective Cohort Study.
Article in International journal of women's health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- The quintessential high-risk profile: advanced management strategies for placenta accreta spectrum in patients with advanced maternal age and IVF conception.BMC pregnancy and childbirth · 2026Review
- Advanced maternal age and assisted reproductive technologies: outcomes, genomics, and real-world evidence.Frontiers in reproductive health · 2026Review
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4 authors.
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Abstract
Purpose: To evaluate maternal and neonatal outcomes following assisted reproductive technology (ART) in advanced maternal age (AMA) primiparous women. Patients and Methods: This retrospective cohort study analyzed 2329 AMA primiparous women (≥35 years) who delivered singleton pregnancies at Northwest Women's and Children's Hospital between January 2016 and January 2020. Participants were stratified into ART (n=422) and spontaneous conception (SC, n=1907) groups. Maternal characteristics, obstetric complications, and neonatal outcomes were compared using multivariate logistic regression to adjust for confounders. Results: ART patients exhibited significantly higher maternal age (37.48 ± 2.44 vs 36.65 ± 1.90 years, *p* < 0.001) and BMI (27.79 ± 3.34 vs 27.61 ± 8.12 kg/m², *p* = 0.016). ART was independently associated with increased risks of preeclampsia (adjusted odds ratio [aOR] 1.89, 95% confidence interval [CI] 1.25-2.86), cesarean delivery (aOR 2.31, 95% CI 1.74-3.06), preterm birth (aOR 1.55, 95% CI 1.10-2.19), and neonatal intensive care unit (NICU) admission (aOR 2.38, 95% CI 1.68-3.37). Conversely, SC pregnancies showed higher rates of preterm premature rupture of membranes (PPROM; 26.43% vs 17.30%, *p* < 0.001). No significant differences were observed in gestational diabetes mellitus (33.18% vs 31.31%, *p* = 0.455) or placental abruption (0.95% vs 1.42%, *p* = 0.313). Conclusion: In AMA primiparas, ART selectively elevates risks of preeclampsia and neonatal morbidity, necessitating targeted antenatal surveillance. These findings underscore the importance of preconception counseling and individualized management for this growing patient population.
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