ReviewNPP - digital psychiatry and neuroscience2025
A practical guide to sequencing in neuropsychiatric research.
Review in NPP - digital psychiatry and neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Stress resilience is associated with transcriptional remodeling in the VTA.Cell reports · 2026Article
- Cellular heterogeneity and multicellular mechanisms in the pathogenesis of late-life depression: insights from single-cell and spatial multi-omics.Frontiers in immunology · 2026Review
- Stress resilience is associated with transcriptional remodeling in the VTA.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Technology and computational analysis to profile RNA and DNA at genome-wide scale has rapidly evolved in the last two decades, with a concomitant rise in their application within neuroscience and psychiatry research. These technologies initially offered "unbiased" insights and the potential to discover previously unconsidered molecular mediators of disease and development. The more recent advent and adoption of single-cell/nucleus and spatial "omics" sequencing provides unprecedented insights into cellular processes within heterogeneous tissues. These advances are especially advantageous in neuropsychiatric research, which faces unique challenges due to the brain's cellular heterogeneity, dynamic development, and the complex, polygenic nature of many psychiatric disorders. Still, different sequencing techniques are better suited for different questions and the most fine-grained (and expensive) approaches are not always necessary. Here, we offer a simple primer on the pros, cons, and best applications for currently available sequencing technologies.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.