Evidence map›Paper›PMID 40787583›Full record

ArticleChem2025

Why Sulfur is Important in Lincosamide Antibiotics.

Kelvin J Y Wu, Elena V Aleksandrova, Paul J Robinson, Amy E Benedetto, Meiyi Yu, Ben I C Tresco, Dominic N Y See, Tong Jiang, Antonio Ramkissoon, Clémence F Dunand and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kelvin J Y WuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Elena V AleksandrovaDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Paul J RobinsonDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Amy E BenedettoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Meiyi YuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Ben I C TrescoDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Dominic N Y SeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Tong JiangDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Antonio RamkissoonDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Clémence F DunandDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Maxim S SvetlovDepartment of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Joonho LeeDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.
Yury S PolikanovDepartment of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA.
Andrew G MyersDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Discovery through chemical synthesis of antibiotics effective against modern bacterial pathogensR01AI168228 · NIAID · HARVARD UNIVERSITY · PI ANDREW G MYERS · 2022 to 2026
$3.8M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Molecular mechanisms of action of ribosome-targeting antibiotics.R01GM132302 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2019 to 2022
$1.3M
Structural basis for ribosome function and inhibition in bacteria.R35GM151957 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI YURY POLIKANOV · 2024 to 2026
$1.2M
Structural basis of Cfr-mediated resistance to antibiotics targeting the bacterial ribosomeR21AI163466 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI POLIKANOV, YURY · 2021 to 2022
$426k
NIAID NIH HHS R01 AI168228NIAID NIH HHS R21 AI163466NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM132302NIGMS NIH HHS R35 GM151957NIH HHS S10 OD021527Wellcome Trust
6 · The paper itself

Abstract

We recently reported the conception and synthesis of cresomycin (

Identifiers

PMID40787583
PMCPMC12333972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.