ArticleAnnals of medicine and surgery (2012)2025
Long noncoding RNA Loxl1-As1 promotes cell apoptosis and suppresses cell proliferation in hepatocellular carcinoma
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hepatocellular carcinoma (HCC) is the second leading cause of death globally. Furthermore, HCC patients have poor long-term survival following curative resection because of a high rate of tumor recurrence. Little is known about the genomic trajectory from primary to early recurrent HCC. The HCC patient survival rate has improved because of improved diagnostic protocols. Increasing numbers of lncRNAs have been revealed to be involved in the carcinogenesis and progression of HCC. Among them, The aim of our study was to examine the prognostic value of Loxl1-As1 expression in patients with HCC. Methods: In this study, we analyzed Loxl1-As1 expression in HCC using tissue microarray and fluorescence Results: Clinically, Loxl1-As1 correlated with poor prognosis of HCC. Loxl1-As1 was downregulated in HCC tissues and cell lines. The ISH assay revealed that Loxl1-As1 expression was significantly decreased in 177 paraffin-embedded samples from patients with HCC compared with non-tumor tissues and Loxl1-As1 expression directly correlated with patient prognosis. Conclusions: Collectively, the findings demonstrate that Loxl1-As1 is over-expressed in HCC patients and associated with a poor prognosis. Additionally, Loxl1-As1 plays an important role in HCC progression. These findings support the notion that lncRNA Loxl1-As1 might be a new driver biomarker and future therapeutic target for HCC patients.
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