Evidence map›Paper›PMID 40787557›Full record

ArticleAnnals of medicine and surgery (2012)2025

Endovascular therapy in large vessel occlusion stroke: navigating critical debates.

Vishal Chavda, Harisinh Parmar, Creed M Stary, Raxit Bhrambhatt, Stefano M Priola, Giuseppe Emmanuele Umana, Kodeeswaran M, Luis Rafel Moscote Salazar, Bipin Chaurasia

Abstract readEditorial
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Vishal ChavdaDepartment of Medicine and Critical Care, Multispecialty, Trauma and ICCU Centre, Sardar Hospital, Ahmadabad, Gujarat, India.
Harisinh ParmarDepartment of Neurosurgery, Hyogo College of Medicine, Nishinomiya, Japan.
Creed M StaryDepartment of Anaesthesia and Perioperative Pain Medicine, Stanford School of Medicine, Stanford University Medical Centre, Stanford, CA, USA.
Raxit BhrambhattDepartment of Medicine and Critical Care, Multispecialty, Trauma and ICCU Centre, Sardar Hospital, Ahmadabad, Gujarat, India.
Stefano M PriolaDivision of Neurosurgery, Health Sciences North, Northern Ontario School of Medicine University, Sudbury, ON, Canada.
Giuseppe Emmanuele UmanaDepartment of Neurosurgery, Trauma and Gamma-Knife Center, Cannizzaro Hospital, Catania, Italy.
Kodeeswaran MDepartment of Neurosurgery, Kilpauk Medical College, Chennai, India.
Luis Rafel Moscote SalazarDepartment of Clinical Research, AV Healthcare Innovators, LLC, Madison, WI, USA.
Bipin ChaurasiaDepartment of Neurosurgery, College of Medical Sciences, Bharatpur, Nepal.ORCID https://orcid.org/0000-0002-8392-2072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endovascular therapy (EVT) has transformed the acute management of large vessel occlusion strokes, with strong evidence from landmark trials validating its effectiveness. However, numerous clinical and procedural controversies remain unresolved ranging from patient selection and treatment windows to management of intracranial atherosclerotic disease and reperfusion-related injury. This editorial critically examines these debates, integrating trial data, mechanistic insights, and expert commentary. We emphasize a need for tailored approaches grounded in imaging, pathophysiology, and patient-centered outcomes. Understanding these unresolved challenges is crucial for refining EVT protocols and improving global stroke care delivery.

Indexed as

endovascular therapyintracranial atherosclerotic disease (ICAD)ischemic strokelarge vessel occlusion stroke (LVOS)mechanical thrombectomyreperfusion injurystroke management

Identifiers

PMID40787557
PMCPMC12333737

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.