ArticleAnnals of medicine and surgery (2012)2025
Investigating the effects of vitamin C administration on the incidence of pharyngocutaneous fistulas after total laryngectomy: a randomized controlled trial.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Background: Pharyngocutaneous fistula represents a significant complication following total laryngectomy. This study aims to explore the relationship between vitamin C administration and the formation of pharyngocutaneous fistulas. Materials and methods: This open-label randomized controlled trial involved 47 patients diagnosed with laryngeal cancer. Participants were randomly allocated to either an intervention group or a placebo group. Those in the intervention group received 1 gram of vitamin C via injection twice daily ( Results: A total of 27.66% (13 patients) developed pharyngocutaneous fistulas. The incidence in the vitamin C group was lower at 21.74%, compared to 33.33% in the control group; however, this difference did not reach statistical significance ( Conclusion: Although this study offers important insights into the potential impact of vitamin C on the postoperative care of laryngeal cancer patients, the results indicate that further research with larger sample sizes and varied methodologies is required to establish definitive conclusions.
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