ArticleAnnals of medicine and surgery (2012)2025
Enteral vitamin a supplementation for the prevention of bronchopulmonary dysplasia in preterm infants: an updated systematic review and meta-analysis.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Take a deep breath: the important role of vitamin A in neonatal lung development and visiting the potential of aerosolized delivery for bronchopulmonary dysplasia prevention.Expert review of respiratory medicine · 2026Article
- Association of caffeine citrate plus vitamin A/D drops with bronchopulmonary dysplasia and respiratory outcomes in preterm infants born at <32 weeks' gestation: a 72-h landmark retrospective cohort study.Frontiers in pediatrics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Material and methods: We searched several databases using Cochrane Central Register of Controlled Trials, MEDLINE, Embase, and ClinicalTrials.gov. We included only placebo-controlled clinical trials on infants born at less than 32 weeks' gestation, who were administered enteral vitamin A supplementation. A random effects model was employed to calculate risk ratios and weighted mean differences. Results: A total of five studies with 1715 participants were included in our meta-analysis. No significant reduction was observed in the incidence of moderate-to-severe bronchopulmonary dysplasia [RR = 0.91, 95% CI (0.70, 1.17), Conclusion: Supplementing premature infants with enteral vitamin A might shorten the duration of noninvasive respiratory support requirement. However, there is a lack of evidence for its superior efficacy in improving the overall health outcomes for premature infants compared to placebo.
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