ArticleAnnals of medicine and surgery (2012)2025
Critical biomarkers in the battle against COVID-19: unveiling thrombotic risks and predictive indicators in Syrian hospitals.
Article in Annals of medicine and surgery (2012), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The global COVID-19 pandemic has caused a significant number of fatalities, placing immense strain on healthcare systems worldwide. It is imperative to comprehend the clinical parameters that influence patient outcomes, especially in resource-limited settings such as Syria. This study specifically focuses on thrombotic laboratory parameters and their role in predicting the severity and mortality of COVID-19 patients. Methods: This prospective, multicenter study was conducted in Al-Razi Hospital and the University Cardiac Surgery Hospital in Aleppo, Syria. It included 60 adult patients diagnosed with SARS-CoV-2 using real-time quantitative polymerase chain reaction, admitted between November 2021 and March 2022. Demographic data, clinical characteristics, and laboratory parameters, including D-dimer, international normalized ratio, fibrinogen, and complete blood count, were collected and analyzed. Statistical analyses were performed using SPSS version 27. Results: Among the 60 patients (42 males, 18 females), the mean age was 63.87 years. Key findings revealed a high mortality rate of 50% among hospitalized patients. Elevated D-dimer levels at admission were significantly associated with increased mortality ( Conclusion: Monitoring thrombotic parameters such as D-dimer levels is crucial in predicting the severity and mortality of COVID-19 in hospitalized patients. These findings highlight the need for targeted therapeutic strategies to improve patient outcomes, particularly in resource-constrained environments like Syria.
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