ArticleFrontiers in immunology2025
A pilot study of the immunological profile and efficacy of rituximab in muscle-specific kinase antibody-positive myasthenia gravis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Italian recommendations for the diagnosis and treatment of myasthenia gravis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
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13 authors.
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Abstract
Purpose: This study summarized the clinical and immunological characteristics of patients with muscle-specific kinase (MuSK) antibody-positive myasthenia gravis (MG), compared their difference with acetylcholine receptor (AChR) antibody-positive MG, and evaluated the therapeutic efficacy of rituximab (RTX) in MuSK-MG. Methods: This study included 10 MuSK-MG patients and 10 new-onset AChR-MG patients. Clinical and immunological data were collected from medical records before RTX treatment. The efficacy of RTX in MuSK-MG was evaluated by MG-specific activities of daily living (MG-ADL) and quantitative MG (QMG) scores. Results: All 10 MuSK-MG patients were female with a mean onset age of 44.3 ± 12.0 years, predominantly presenting with bulbar muscle weakness (90%) and limb weakness (80%). Compared to AChR-MG, MuSK-MG showed higher MG-ADL and QMG scores (P < 0.05), along with more frequent bulbar involvement at disease onset (P = 0.036). Immunological analyses revealed elevated CD19 Conclusion: MuSK-MG showed distinct clinical and immunological features, including predominant bulbar/limb onset, elevated CD19
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