Evidence map›Paper›PMID 40787453›Full record

ArticleFrontiers in immunology2025

CD226

Ping Zhao, Saizhe Song, Song Zhang, Cheng Peng, Wei Cheng, Xin Chang, Changhao Xie, Zhongli Hu, Cuiping Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ping Zhao *Jiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Saizhe Song *Jiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Song ZhangDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Cheng PengDepartment of Rheumatology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Wei ChengDepartment of Dermatology, Changshu No 2 People's Hospital, Suzhou, China.
Xin ChangJiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.
Changhao XieDepartment of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Zhongli HuDepartment of Hematology, The First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Cuiping LiuJiangsu Institute of Clinical Immunology and Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Primary Sjögren's syndrome (pSS) is a systemic autoimmune disorder characterized by lymphocytic infiltration of exocrine glands, leading to sicca symptoms and systemic complications. CD226, a co-stimulatory receptor implicated in the pathogenesis of multiple autoimmune diseases including systemic lupus erythematosus (SLE), rheumatoid arthritis(RA), and pSS, regulates immune cell activation. However, the specific role of CD226+ B cells in pSS pathogenesis remains unclear. This study aims to elucidate the functional contribution of CD226 Methods: The percentages of CD226 on T cells, B cells, CD56 Results: CD226 expression in the peripheral blood of pSS patients was significantly increased on T cells, CD19 Discussion: CD226

Indexed as

Antigens, Differentiation, B-LymphocyteAntigens, Differentiation, T-LymphocyteB-LymphocytesSjogren's SyndromeAdultAgedBiomarkersCytokinesFemaleHumansKiller Cells, NaturalLymphocyte ActivationMaleMiddle AgedSalivary GlandsT Lineage-Specific Activation Antigen 1Antigens, Differentiation, B-LymphocyteAntigens, Differentiation, T-LymphocyteBiomarkersCytokinesT Lineage-Specific Activation Antigen 1B cellsCD226costimulatory moleculecytokinesprimary Sjögren’s syndrome

Identifiers

PMID40787453
PMCPMC12331654

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.