Evidence map›Paper›PMID 40787450›Full record

ReviewFrontiers in immunology2025

Emerging frontiers in epigenetic-targeted therapeutics for pediatric neuroblastoma.

Xiaokang Wang, Gengrui Xu, Hongyan Ma, Xiaoyan Deng, Guiping Ma

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaokang WangDepartment of Pharmacy, Shenzhen Longhua District Central Hospital, Affiliated Longhua Hospital of Shenzhen University, Shenzhen, China.
Gengrui XuDepartment of Pharmacy, Shenzhen Longhua District Central Hospital, Affiliated Longhua Hospital of Shenzhen University, Shenzhen, China.
Hongyan MaDepartment of Pharmacy, Shenzhen Longhua District Central Hospital, Affiliated Longhua Hospital of Shenzhen University, Shenzhen, China.
Xiaoyan DengCenter of Community Health Service Management, Shenzhen Longhua District Central Hospital, Shenzhen, China.
Guiping MaBeijing University of Chinese Medicine Affiliated Shenzhen Hospital (Longgang), Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuroblastoma (NB), the most prevalent extracranial solid malignancy in children, poses significant therapeutic challenges, particularly concerning high-risk subtypes characterized by an immunologically "cold" phenotype. These tumors evade immune surveillance through mechanisms such as impaired antigen presentation and immunosuppressive microenvironment formation. Despite the incorporation of immunotherapies (

Indexed as

Antineoplastic AgentsEpigenesis, GeneticNeuroblastomaAnimalsChildDNA MethylationGene Expression Regulation, NeoplasticHistone Deacetylase InhibitorsHumansMolecular Targeted TherapyAntineoplastic AgentsHistone Deacetylase Inhibitorsepigenetic regulationimmunologically coldpediatric neuroblastomasmall-molecule targeted agentstherapeutic strategies

Identifiers

PMID40787450
PMCPMC12331715

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.