ArticleIranian journal of child neurology2025
Constipation in Children with Cerebral Palsy: Prevalence, Clinical Manifestations, and Polyethylene glycol vs. Lactulose Efficacy.
Article in Iranian journal of child neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Malnutrition in Children with Congenital Zika Virus Syndrome: A Systematic Review.Maternal and child health journal · 2026Pooled it
- The Gut Microbiome in Early Ontogeny: Implications for Brain and Immune System Development.Journal of developmental biology · 2026Review
- Usefulness of ultrasound in diagnosing constipation in children: a narrative review.Frontiers in pediatrics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Cerebral palsy (CP) is a neurological disorder causing impaired movement control. Constipation is a common issue among these patients, with the prevalence ranging from 26% to 74%. This study aims to investigate the prevalence of constipation, examine associated symptoms, and compare the effects of commonly used drugs, including Lactulose and Polyethylene Glycol (PEG), in children with CP. These drugs can improve constipation management in this population and prevent serious complications, such as intestinal obstruction and bleeding. Materials & Methods: The present research was a prospective cross-sectional study of 48 children and adolescents aged 1 to 15 with CP. According to our definition of constipation based on the ROME IV criteria, the prevalence of constipation in children with CP was calculated. Patients were randomly divided into two groups: Group 1 received treatment with PEG, while Group 2 received treatment with Lactulose. The patients were followed up one month later and then every three months to assess treatment response and monitor clinical symptoms. Results: At both 12 and 24 weeks following the initiation of the treatment, a significant increase in the frequency of defecation per week was observed, accompanied by a notable decrease in the frequency of fecal incontinence in both groups. After 24 weeks of treatment, the defecation frequency increased from 1.5 to 6.3 in Group 1 (PEG group) and 1.6 to 5.7 in Group 2 (Lactulose group). Fecal incontinence reduced from initial values of 1.8 and 1.9 to 1.2 and 1.5 in Groups 1 and 2, respectively. Conclusion: This study confirms that constipation is a common problem among children with CP. According to the obtained findings, PEG appeared to be more effective than Lactulose in managing constipation in children with CP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.