Evidence map›Paper›PMID 40787210›Full record

ArticleThe Canadian journal of statistics = Revue canadienne de statistique2025

Robust causal inference for point exposures with missing confounders.

Alexander W Levis, Rajarshi Mukherjee, Rui Wang, Sebastien Haneuse

Abstract read
In one paragraph

Article in The Canadian journal of statistics = Revue canadienne de statistique, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alexander W LevisDepartment of Statistics & Data Science, Carnegie Mellon University, Pittsburgh, USA.
Rajarshi MukherjeeDepartment of Biostatistics, Harvard University, Boston, USA.
Rui WangDepartment of Biostatistics, Harvard University, Boston, USA.
Sebastien HaneuseDepartment of Biostatistics, Harvard University, Boston, USA.

Funding

Robust methods for missing data in electronic health records-based studiesR01DK128150 · NIDDK · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI HANEUSE, SEBASTIEN · 2021 to 2024
$2.1M
Bayesian machine learning for complex missing data and causal inference with a focus on cardiovascular and obesity studiesR01HL166324 · NHLBI · UNIVERSITY OF FLORIDA · PI Michael J Daniels · 2023 to 2026
$2.1M
NHLBI NIH HHS R01 HL166324NIDDK NIH HHS R01 DK128150
6 · The paper itself

Abstract

Large observational databases are often subject to missing data. As such, methods for causal inference must simultaneously handle confounding and missingness; surprisingly little work has been done at this intersection. Motivated by this, we propose an efficient and robust estimator of the causal average treatment effect from cohort studies when confounders are missing at random. The approach is based on a novel factorization of the likelihood that, unlike alternative methods, facilitates flexible modelling of nuisance functions (e.g., with stateof-the-art machine learning methods) while maintaining nominal convergence rates of the final estimators. Simulated data, derived from an electronic health record-based study of the long-term effects of bariatric surgery on weight outcomes, verify the robustness properties of the proposed estimators in finite samples. Our approach may serve as a theoretical benchmark against which ad-hoc methods may be assessed.

Indexed as

Causal inferencemissing datamultiply robustPrimary 62G20Secondary 62G35semiparametric theory

Identifiers

PMID40787210
PMCPMC12331136

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.