ArticleJournal of multidisciplinary healthcare2025
Nonlinear Association Between Red Cell Distribution Width-to-Albumin Ratio and Retinopathy: A Cross-Sectional Study.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The red cell distribution width-to-albumin ratio (RAR), a marker of systemic inflammation and nutritional status, has been associated with diabetic retinopathy. However, its relationship with retinopathy in a nationally representative sample of US adults aged 40 and older, including both diabetic and nondiabetic individuals, and the potential nonlinear association remains underexplored. Patients and Methods: This cross-sectional study included 4,753 adults aged 40 and older from the National Health and Nutrition Examination Survey (NHANES) 2005-2008. Retinopathy was evaluated through fundus photography and classified based on the Early Treatment Diabetic Retinopathy Study (ETDRS) grading protocol. Nonlinear associations between RAR and retinopathy risk were evaluated using generalized additive models, with a two-piecewise linear regression employed to identify the inflection point. Results: The prevalence of retinopathy increased with higher quartiles of RAR ( Conclusion: RAR exhibits a nonlinear association with retinopathy and may serve as a risk stratification tool in clinical and public health settings.
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