ArticleCrystal growth & design2025
Nonclassical Crystallization of the L‑Tartrate Salt of Cyamemazine.
Article in Crystal growth & design, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study investigates the nonclassical crystallization of cyamemazine L-tartrate, a kryptoracemic salt of the antipsychotic drug cyamemazine. The crystallization pathway was studied via slurry conversion of a suspension of cyamemazine and L-tartaric acid in 2-propanol to the salt. Notably, the system transitioned through an intermediate droplet phase, which subsequently coalesced to form a dense phase. Both intermediate phases exhibited liquid crystalline character when observed under a polarized light microscope. The droplets demonstrated birefringence and a distinct Maltese cross extinction pattern, confirming their liquid crystalline nature. The dense phase revealed a fan-like texture when isolated and examined between glass slides. Comprehensive analyses of the intermediate droplet phase and the dense phase were conducted using solution
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