Evidence map›Paper›PMID 40787073›Full record

ArticleJournal for vascular ultrasound : JVU2025

Clinical Risk Factors for Stroke and Associations with Microembolic Signals on Transcranial Doppler.

Abdullah A Adil, Carol C Mitchell, Thomas D Cook, Jenna Maybock, Nirvedh H Meshram, Tomy Varghese, Stephanie M Wilbrand, Robert J Dempsey

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal for vascular ultrasound : JVU, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Abdullah A AdilDepartment of Otolaryngology - Head and Neck Surgery, University of Michigan.
Carol C MitchellDepartment of Medicine, Cardiovascular Division, University of Wisconsin School of Medicine and Public Health.
Thomas D CookDepartment of Biostatistics & Medical informatics, University of Wisconsin School of Medicine and Public Health.
Jenna MaybockDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health.
Nirvedh H MeshramAdvanced Micro Devices, Inc.
Tomy VargheseDepartment of Medical Physics, University of Wisconsin-Madison.
Stephanie M WilbrandDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health.
Robert J DempseyDepartment of Neurological Surgery, University of Wisconsin School of Medicine and Public Health.

Funding

Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingR01HL147866 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2020 to 2023
$2.9M
Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
In-vivo Quantitative Ultrasound Imaging of Carotid Plaque Validated with 3D Reconstructed Histopathology SectionsF31HL141008 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI STEFFEL, CATHERINE NICOLE · 2018 to 2019
$64k
NHLBI NIH HHS F31 HL141008NHLBI NIH HHS R01 HL147866NINDS NIH HHS R01 NS064034
6 · The paper itself

Abstract

Introduction: Transcranial Doppler (TCD) has been used to identify microembolic signals (MES) in individuals with carotid atherosclerosis (CAS). MES are hypothesized to originate from unstable carotid plaque and have been identified in symptomatic and asymptomatic individuals with CAS. The purpose of this study is to examine the relationship of clinical risk factors for stroke (CRFs) and the presence of MES in patients with advanced CAS. Methods: Participants scheduled for carotid endarterectomy (CEA) (>60% stenosis NASCET and ACAS Criteria) were preoperatively evaluated for CRFs and the presence MES with TCD. Kendall's tau correlation coefficients, Pearson χ2, and logistic regression analysis were used to examine the relationship between MES and CRFs. Results: Participants (n=89) had a median (interquartile range) age of 71(13) years, 30 (33.7%) were female, and 53(59.6%) were symptomatic. MES were detected in 32 (36%) participants. There was significant evidence of association between MES with older age (p =0.026) and male sex (p =0.007). No other clinical variables showed significant association with MES (all p-values>0.05). Logistic regression demonstrated that a model including age(p=0.018), sex(p=0.013) and hyperlipidemia(p=0.083) was significantly associated with the presence of MES (p=0.001). Conclusion: MES were associated with older age and male sex in a cohort with advanced carotid atherosclerosis. Symptomatic status was not a predictor for MES in this cohort, suggesting that plaques in both symptomatic and asymptomatic individuals have the ability to release microemboli, highlighting the need for further work to be done to identify unstable plaques.

Identifiers

PMID40787073
PMCPMC12330219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.