ArticleFrontiers in pediatrics2025
Correlation between tidal breathing pulmonary function, exhaled nitric oxide and airway hyperresponsiveness in children aged 0-3 years with suspected asthma.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Development and Internal Evaluation of a Clinical-Physiological Model for Predicting Methacholine-Defined Airway Hyperresponsiveness in Children Aged 0-3 Years.Journal of asthma and allergy · 2026Article
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Authors and funding
8 authors.
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Abstract
Objective: To investigate the correlation between tidal breathing pulmonary function parameters combined with mixed exhaled gas nitric oxide values and the degree of airway hyperresponsiveness (AHR) in children aged 0-3 years with suspected asthma. Methods: In this retrospective study, we collected baseline clinical data, tidal breathing pulmonary function parameters (measured before methacholine inhalation), fractional exhaled nitric oxide (FeNO) levels, and methacholine challenge test (MCT) results from 818 pediatric asthma patients treated at the Children's Hospital of Chongqing Medical University between January 2021 and June 2023. Baseline data, tidal respiratory pulmonary function parameters, and FeNO values were used to analyze their correlation with AHR. Ordinal multiclass logistic regression analysis was used to identify factors influencing AHR. The receiver operating characteristic (ROC) curve was performed to evaluate the efficacy of predicting AHR using tidal breathing pulmonary function parameters and FeNO values. Results: Intergroup comparisons showed significant differences in age, weight, height, FeNO, TPTEF/TE, RR, TI/TE, TEF50/TIF50, and PTFE/TEF25 ( Conclusions: Our study revealed that Current airway inflammation and airway obstruction predicted AHR at this point.FeNO, RR, PTEF/TEF25, and age were effective predictive parameters for the degree of AHR in children aged 0-3 years with suspected asthma; FeNO >14 ppb served as an independent factor suggesting AHR in children at methacholine concentrations of 8 mg/ml, and the combined parameters showed better predictive efficacy.
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