ArticleInternational journal of general medicine2025
The Duration of Prophylactic Antibiotic Use for Esophageal Cancer Patients with Postoperative Infection and Nutritional Status.
Article in International journal of general medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To verify the hypothesis that "the prophylaxis use time of antibiotics after esophageal cancer (EC) surgery ≤24 hours is associated with a lower postoperative infection rate and improvement of nutritional indicators", a retrospective cohort analysis was conducted to compare the infection incidence and differences in serum nutritional indicators among patients with different medication durations (< 24 hours, 24-48 hours, > 48 hours), and to identify independent risk factors for postoperative infection. Methods: A retrospective analysis was conducted on the data of 566 patients who underwent EC surgery in Affiliated Hospital of North Sichuan Medical College from January 2020 to October 2022. Patients were divided into three groups based on the duration of postoperative antibiotic prophylaxis: Group A (<24 hours), Group B (24-48 hours), and Group C (>48 hours). The differences in postoperative infection incidence and nutritional indicators [serum albumin (ALB), prealbumin (PA), hemoglobin (Hb) levels] among the three groups of patients were compared. Multivariate logistic regression analysis was performed to analyze the risk factors. Results: There existed a significant difference in the nutritional indicators among the patients in the three groups after surgery ( Conclusion: This study verified the hypothesis that "antibiotic use time ≤24 hours is associated with a lower infection rate trend and an increase in nutritional indicators", but the causal relationship could not be established due to the retrospective design. Age, pulmonary ventilation function, length of hospital stay, and preoperative malnutrition were independent risk factors for postoperative infection, supporting the clinical formulation of individualized antibiotic regimens based on the association between medication duration and infection/nutrition.
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