Evidence map›Paper›PMID 40786864›Full record

ArticleFrontiers in genetics2025

Case Report: Decoding genetic risks of vascular parkinsonism: a case series.

Ali Shalash, Salma El-Shafie, Peter George, Tamer Roushdy, Mai Fathy, Mohamed H Yousef, Mahmoud El-Belkimy, Mohamed Ossama Abdulghani, Mohamed Salama

Abstract readCase Reports
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In one paragraph

Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ali Shalash *Neurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Salma El-Shafie *Biology Department, The American University in Cairo, Cairo, Egypt.
Peter GeorgeNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Tamer RoushdyNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mai FathyNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed H YousefInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.
Mahmoud El-BelkimyNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed Ossama AbdulghaniNeurology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Mohamed SalamaInstitute of Global Health and Human Ecology, The American University in Cairo, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Vascular parkinsonism (VaP) is a subtype of parkinsonism which needs better characterization of its risks and determinants. Objective: The aim of this report is to present an understanding of genetic risks of vascular parkinsonism. Methods: Five participants diagnosed with VaP were recruited and Whole Exome Sequencing (WES) was performed to analyze deleterious variants in relevant genes associated with vascular and parkinsonian diseases. Results: We identified several candidate risk variants for VaP in our patients, particularly in LRRK2, PLA2G6, TGM6, BSN, UBR4, CD36 and NOTCH3, that are different from the classical Parkinson's disease -associated variants. Conclusion: In this case series we highlighted the complexity of genetic contributions to VaP through predicted deleterious variants in genes associated with parkinsonism, cerebrovascular disease as well as collagen-related genes.

Indexed as

Egyptiangeneticsleukoencephalopathyparkinsonismvascular

Identifiers

PMID40786864
PMCPMC12331493

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